MTDB-Alkyne
MTDB-Alkyne (MTDB-Alk) is a β-coronavirus pseudoknot RNA-binding ligand that binds to the β-coronavirus pseudoknot RNA structure on the SARS-CoV-2 genome. MTDB-Alkyne can be used to synthesize Proximity-Induced Nucleic Acid Degrader (PINAD) for degrading SARS-CoV-2 RNA. MTDB-Alkyne is applicable to research related to the development of SARS-CoV-2-targeted RNA probes.
For research use only. We do not sell to patients.
- CAS No.: 2923694-73-7
- Formula: C21H25N5O2S
- Molecular Weight:411.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
MTDB-Alkyne (MTDB-Alk) binds to the betacoronavirus pseudoknot RNA structure on the SARS‑CoV‑2 genome, and has no intrinsic RNA degrading activity; it can also be conjugated via CuAAC click chemistry to generate the PINAD-class molecule MTDB‑imi6[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2923694-73-7
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Molecular Weight 411.52
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Formula C21H25N5O2S
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SMILES
O=C(C1=C(NC(N2CCN(CCC2)CC3=CSC(C)=N3)=O)C=CC=C1)NCC#C
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Synonyms
MTDB-Alk
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MTDB-Alkyne Related Classifications
HY-158905 Related Classifications
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