ND-011458
Based on 1 Customer Validation
ND-011458 is an Antibacterial agent, a QcrB inhibitor, and also an inhibitor of cytochrome bcc:aa3 oxidase function. ND-011458 binds to the QcrB subunit of cytochrome bcc:aa3 oxidase. ND-011458 inhibits ATP formation. When used in combination with Clofazimine (HY-B1046), ND-011458 exhibits bactericidal activity against Mycobacterium abscessus. ND-011458 can be used in studies related to Mycobacterium abscessus pulmonary infections.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.92%
- CAS 番号: 1648720-01-7
- 分子式: C28H26ClF3N4O2
- 分子量:542.98
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
ND-011458 potently inhibits the growth of multiple subspecies of the *Mycobacterium abscessus* complex and depletes their intracellular ATP[1].
ND-011458 directly inhibits the respiration of purified recombinant *Mycobacterium abscessus* cyt-bcc:aa3 oxidase, confirming that it targets this enzyme complex[1].
ND-011458 (0.1-20 μM; 3 days, checkerboard assay) exerts an additive effect with Clofazimine to inhibit the growth of *Mycobacterium abscessus* (FIC index = 0.82); their combination (10 μM ND-011458 + 8 μM CFZ) exhibits bactericidal activity, reducing the bacterial load by approximately 1 log within 4 days[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1648720-01-7
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性状 Solid
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分子量 542.98
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分子式 C28H26ClF3N4O2
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Color White to off-white
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SMILES
ClC1=CN2C(C(NCC3=CC=C(N4CCC(C5=CC=C(OC(F)(F)F)C=C5)CC4)C=C3)=O)=C(C)N=C2C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ND-011458 関連分類
HY-183075 関連分類
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Keywords
- ND-011458
- 1648720-01-7
- ND011458
- ND 011458
- Bacterial
- ATP Synthase
- mycobacterium abscessus pulmonary infections
- QN-binding pocket
- M. abscessus subsp. abscessus S morphotype
- Mycobacterium abscessus complex
- M. abscessus subsp. abscessus R morphotype
- Clofazimine
- QcrA
- cytochrome bcc:aa3 oxidase
- Mycobacterium abscessus
- QcrB
- Inhibitor
- inhibitor
- inhibit