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Cat. No.: HY-183075

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ND-011458

ND-011458 is an Antibacterial agent, a QcrB inhibitor, and also an inhibitor of cytochrome bcc:aa3 oxidase function. ND-011458 binds to the QcrB subunit of cytochrome bcc:aa3 oxidase. ND-011458 inhibits ATP formation. When used in combination with Clofazimine (HY-B1046), ND-011458 exhibits bactericidal activity against Mycobacterium abscessus. ND-011458 can be used in studies related to Mycobacterium abscessus pulmonary infections.

For research use only. We do not sell to patients.

CAS No.: 1648720-01-7
Formula: C₂₈H₂₆ClF₃N₄O₂
Molecular Weight:542.98

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ND-011458 Chemical Structure

CAS No.: 1648720-01-7

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

In Vitro

ND-011458 potently inhibits the growth of multiple subspecies of the *Mycobacterium abscessus* complex and depletes their intracellular ATP^[1].
ND-011458 directly inhibits the respiration of purified recombinant *Mycobacterium abscessus* cyt-bcc:aa₃ oxidase, confirming that it targets this enzyme complex^[1].
ND-011458 (0.1-20 μM; 3 days, checkerboard assay) exerts an additive effect with Clofazimine to inhibit the growth of *Mycobacterium abscessus* (FIC index = 0.82); their combination (10 μM ND-011458 + 8 μM CFZ) exhibits bactericidal activity, reducing the bacterial load by approximately 1 log within 4 days^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1648720-01-7
Molecular Weight 542.98
Formula C₂₈H₂₆ClF₃N₄O₂
SMILES

ClC1=CN2C(C(NCC3=CC=C(N4CCC(C5=CC=C(OC(F)(F)F)C=C5)CC4)C=C3)=O)=C(C)N=C2C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mathiyazakan V, et al. The Mycobacterium abscessus cytochrome bcc:aa₃ oxidase structure paves the way for an agent targeting subunit QcrB. Nat Commun. Published online April 3, 2026. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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