2. Anti-infection Membrane Transporter/Ion Channel
  3. Bacterial ATP Synthase
  4. ND-011458

ND-011458 is an Antibacterial agent, a QcrB inhibitor, and also an inhibitor of cytochrome bcc:aa3 oxidase function. ND-011458 binds to the QcrB subunit of cytochrome bcc:aa3 oxidase. ND-011458 inhibits ATP formation. When used in combination with Clofazimine (HY-B1046), ND-011458 exhibits bactericidal activity against Mycobacterium abscessus. ND-011458 can be used in studies related to Mycobacterium abscessus pulmonary infections.

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ND-011458

ND-011458 Chemical Structure

CAS No. : 1648720-01-7

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ND-011458 Related Antibodies

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Description

ND-011458 is an Antibacterial agent, a QcrB inhibitor, and also an inhibitor of cytochrome bcc:aa3 oxidase function. ND-011458 binds to the QcrB subunit of cytochrome bcc:aa3 oxidase. ND-011458 inhibits ATP formation. When used in combination with Clofazimine (HY-B1046), ND-011458 exhibits bactericidal activity against Mycobacterium abscessus. ND-011458 can be used in studies related to Mycobacterium abscessus pulmonary infections[1].

In Vitro

ND-011458 potently inhibits the growth of multiple subspecies of the *Mycobacterium abscessus* complex and depletes their intracellular ATP[1].
ND-011458 directly inhibits the respiration of purified recombinant *Mycobacterium abscessus* cyt-bcc:aa3 oxidase, confirming that it targets this enzyme complex[1].
ND-011458 (0.1-20 μM; 3 days, checkerboard assay) exerts an additive effect with Clofazimine to inhibit the growth of *Mycobacterium abscessus* (FIC index = 0.82); their combination (10 μM ND-011458 + 8 μM CFZ) exhibits bactericidal activity, reducing the bacterial load by approximately 1 log within 4 days[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ND-011458 Related Antibodies
Molecular Weight

542.98

Formula

C28H26ClF3N4O2
CAS No.
SMILES

ClC1=CN2C(C(NCC3=CC=C(N4CCC(C5=CC=C(OC(F)(F)F)C=C5)CC4)C=C3)=O)=C(C)N=C2C=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ND-011458 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ND-0114581648720-01-7ND011458ND 011458BacterialATP Synthasemycobacterium abscessus pulmonary infectionsQN-binding pocketM. abscessus subsp. abscessus S morphotypeMycobacterium abscessus complexM. abscessus subsp. abscessus R morphotypeClofazimineQcrAcytochrome bcc:aa3 oxidaseMycobacterium abscessusQcrBInhibitorinhibitorinhibit

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