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Cat. No.: HY-147682

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NF-κB-IN-5

NF-κB-IN-5 (compound 4d) is an orally active and potent NF-κB inhibitor by interacting directly with NF-κB. NF-κB-IN-5 shows antitumor activity against human cancer cell lines (HCT116, U87-MG, HepG2, BGC823, PC9), with IC₅₀ values of 5.35, 2.81, 2.83, 2.02 and 3.90 μM, respectively. NF-κB-IN-5 induces apoptosis in U87-MG tumor cell and cell cycle arrest in G0/G1 phase.

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CAS No.: 2425675-52-9
Formule: C₂₃H₂₇N₃O₄
Masse moléculaire:409.48

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

NF-κB-IN-5 Chemical Structure

CAS No.: 2425675-52-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vivo
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform NF-κB :

Cellular Effect

Cell Line	Type	Value	Description	References
BGC-823	IC₅₀	2.02 μM Compound: 4d	Antiproliferation activity against human BGC823 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Antiproliferation activity against human BGC823 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 32546298]
HCT-116	IC₅₀	5.35 μM Compound: 4d	Antiproliferation activity against human HCT116 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Antiproliferation activity against human HCT116 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 32546298]
HepG2	IC₅₀	2.83 μM Compound: 4d	Antiproliferation activity against human HepG2 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Antiproliferation activity against human HepG2 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 32546298]
PC-9	IC₅₀	3.9 μM Compound: 4d	Antiproliferation activity against human PC9 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Antiproliferation activity against human PC9 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 32546298]
U-87MG ATCC	IC₅₀	2.81 μM Compound: 4d	Antiproliferation activity against human U87MG cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Antiproliferation activity against human U87MG cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 32546298]

In Vivo

NF-κB-IN-5 (C57BL/6 mice bearing MC38, 40.0 mg/kg, PO, for 12 days, once a day) shows promising antitumor activity against mice colon tumor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 2425675-52-9
Masse moléculaire 409.48
Formule C₂₃H₂₇N₃O₄
SMILES

O=C(N/N=C/C1=C/CC[C@]2(C)[C@@]([C@@]([C@](CC1)([H])C3=C)([H])OC3=O)([H])O2)NC4=CC=C(C)C=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Jia X, et al. Synthesis, cytotoxicity, and in vivo antitumor activity study of parthenolide semicarbazones and thiosemicarbazones. Bioorg Med Chem. 2020 Jul 1;28(13):115557. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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