1. NF-κB
    Apoptosis
  2. NF-κB
    Apoptosis
  3. NF-κB-IN-5

NF-κB-IN-5 

Cat. No.: HY-147682
Handling Instructions

NF-κB-IN-5 (compound 4d) is an orally active and potent NF-κB inhibitor by interacting directly with NF-κB. NF-κB-IN-5 shows antitumor activity against human cancer cell lines (HCT116, U87-MG, HepG2, BGC823, PC9), with IC50 values of 5.35, 2.81, 2.83, 2.02 and 3.90 μM, respectively. NF-κB-IN-5 induces apoptosis in U87-MG tumor cell and cell cycle arrest in G0/G1 phase.

For research use only. We do not sell to patients.

NF-κB-IN-5 Chemical Structure

NF-κB-IN-5 Chemical Structure

CAS No. : 2425675-52-9

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Description

NF-κB-IN-5 (compound 4d) is an orally active and potent NF-κB inhibitor by interacting directly with NF-κB. NF-κB-IN-5 shows antitumor activity against human cancer cell lines (HCT116, U87-MG, HepG2, BGC823, PC9), with IC50 values of 5.35, 2.81, 2.83, 2.02 and 3.90 μM, respectively. NF-κB-IN-5 induces apoptosis in U87-MG tumor cell and cell cycle arrest in G0/G1 phase[1].

In Vivo

NF-κB-IN-5 (C57BL/6 mice bearing MC38, 40.0 mg/kg, PO, for 12 days, once a day) shows promising antitumor activity against mice colon tumor[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

409.48

Formula

C23H27N3O4

CAS No.
SMILES

O=C(N/N=C/C1=C/CC[[email protected]]2(C)[[email protected]@]([[email protected]@]([[email protected]](CC1)([H])C3=C)([H])OC3=O)([H])O2)NC4=CC=C(C)C=C4

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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NF-κB-IN-5
Cat. No.:
HY-147682
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