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Cat. No.: HY-189687

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NH2-PEG3-VC-PAB

NH2-PEG3-VC-PAB is an ADC payload-linker conjugate. NH2-PEG3-VC-PAB can be used for the synthesis of the ADC CRB-701.

For research use only. We do not sell to patients.

Formula: C₂₇H₄₄N₆O₁₀
Molecular Weight:612.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NH2-PEG3-VC-PAB Chemical Structure

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Use of MCE Products

One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

NH2-PEG3-VC-PAB is an ADC payload-linker conjugate. NH2-PEG3-VC-PAB can be used for the synthesis of the ADC CRB-701^[1].

All Drug-Linker Conjugates for ADC Isoforms :

In Vitro

Antibody-drug conjugates (ADCs) employ drug-linker conjugates composed of an active cytotoxic drug and an appropriate linker. These conjugates, when attached to monoclonal antibodies, are used to prepare ADCs, which are highly selective and cytotoxic targeted drugs against cancer cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 612.67
Formula C₂₇H₄₄N₆O₁₀
SMILES

O=C(O)OCC1=CC=C(C=C1)NC([C@@H](NC([C@H](C(C)C)NC(COCCOCCOCCN)=O)=O)CCCNC(N)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sun Z, et al. CRB-701: A Second-generation Nectin-4-Targeted Antibody-Drug Conjugate with Optimized Stability and Pharmacokinetics for the Treatment of Solid Tumors. Cancer research communications. 2026 Sep 01;6(9):2164-2176.

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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