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Cat. No.: HY-15499

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K-832

K-832 is an orally active IL-1β secretion inhibitor. K-832 can be used in the research of rheumatoid arthritis.

For research use only. We do not sell to patients.

CAS No.: 225666-85-3
Formula: C₂₄H₁₉ClN₂OS
Molecular Weight:418.94

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

K-832 Chemical Structure

CAS No.: 225666-85-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

K-832 is an orally active IL-1β secretion inhibitor. K-832 can be used in the research of rheumatoid arthritis^[1]^[2].

IC₅₀ & Target^[1]^[2]

IL-1β

All Interleukin Related Isoforms :

Chemical Information

CAS No. 225666-85-3
Molecular Weight 418.94
Formula C₂₄H₁₉ClN₂OS
SMILES

O=C1C=C(C2=CC=C(Cl)C=C2)C(C3=CC=C(SC)C=C3)=NN1CC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dumont F J. The interleukin-1 families of cytokines and receptors: therapeutic potential for immunomodulation and the treatment of inflammatory disorders. Expert Opinion on Therapeutic Patents, 2006, 16(7): 879-912.

[2]. Halim S A, et al. Attempt to explore the binding mechanism of IL-1β inhibitors via molecular docking studies. Med. Chem, 2015, 5(10): 452-457.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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K-832

All Interleukin Related Isoforms