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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
109 Results for "
CK2,
" in MedChemExpress (MCE) Product Catalog:
Products (109)
109 Results for "CK2," in MCE Product Catalog:
Cat. No.: HY-108606R
CAS No.: 942289-87-4
Target:
Research Areas:
PI-828 (Standard) is the analytical standard of PI-828 (HY-108606). This product is intended for research and analytical applications. PI-828 is a dual PI3K and casein Kinase 2 (CK2) inhibitor with IC50s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid Kinase assay, respectively .
Cat. No.: HY-181022
CAS No.: 1541248-36-5
Target:
Research Areas:
BMS-135 is a potenr, selective and ATP-competitive casein kinase 2 (CK2) inhibitor with IC50 of 0.8 and 0.3 nM for CK2αandCK2α′ isoforms. BMS-135 can simulate the structure of ATP and bind to the active pocket of CK2, thereby inhibiting its serine/threonine phosphorylation function. BMS-135 can inhibit cells proliferation and shows anti-tumor effect. BMS-135 can be used for research of colon cancer .
Cat. No.: HY-P76825
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CSNK2A1; Casein Kinase II Alpha 1 Polypeptide Pseudogene; Casein Kinase 2 Alpha 1; Non-Specific Serine/Threonine Protein Kinase; Casein Kinase II Subunit Alpha; Casein Kinase II Alpha 1 Subunit; CKa1; CK2 Catalytic Subunit Alpha; CKa2; Protein Kinase CK2
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-P76826
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CSNK2A1; Casein Kinase II Alpha 1 Polypeptide Pseudogene; Casein Kinase 2 Alpha 1; Non-Specific Serine/Threonine Protein Kinase; Casein Kinase II Subunit Alpha; Casein Kinase II Alpha 1 Subunit; CKa1; CK2 Catalytic Subunit Alpha; CKa2; Protein Kinase CK2
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-180987
CAS No.: 1541248-45-6
Target:
Research Areas:
BMS-159 is an orally active, direct phosphate prodrug of BMS-135. BMS-135 is a potent ATP-competitive inhibitor of CK2. BMS-159 can be used in the research of neurological disorders and tumors .
Cat. No.: HY-P702741
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: CSNK2A1; Casein Kinase II Alpha 1 Polypeptide Pseudogene; Casein Kinase 2 Alpha 1; Non-Specific Serine/Threonine Protein Kinase; Casein Kinase II Subunit Alpha; Casein Kinase II Alpha 1 Subunit; CKa1; CK2 Catalytic Subunit Alpha; CKa2; Protein Kinase CK2
Species:
Human
Source:
E. coli
Cat. No.: HY-183265
Research Areas:
GO847 is an orally active casein kinase 2 (CK2) inhibitor with an IC50 of 40.2 nM. GO847 increases intracellular ATP levels, impairs Mitochondrial metabolic flexibility, and promotes excessive mitochondrial ROS production. GO847 alters the period length of cellular circadian rhythms. GO847 inhibits the growth of acute myeloid leukemia cells. GO847 can be used for the research of acute myeloid leukemia .
Cat. No.: HY-171744
CAS No.: 1333382-32-3
Target:
Research Areas:
CX-5279 is an efficient and selective CK2 inhibitor with IC50 values for nCK2 and CK2α of 2.73 and 0.91 nM, respectively. CX-5279 is sensitive to mutations at Val66, Ile174, and V66I174AA, with IC50 values of 13.8, 12.5, and 23.35 nM, respectively. CX-5279's inhibitory activity against PIM1 is very weak, with a IC50 value of 8.52 μM. CX-5279 exhibits anti-proliferative activity in various cancer cell lines. CX-5279 can be used for research on cancers such as pancreatic cancer and leukemia .
Cat. No.: HY-184458
CAS No.: 1009821-64-0
Target:
Research Areas:
CX-5279 free acid is an efficient and selective CK2 inhibitor with IC50 values for nCK2 and CK2α of 2.73 and 0.91 nM, respectively. CX-5279 free acid is sensitive to mutations at Val66, Ile174, and V66I174AA, with IC50 values of 13.8, 12.5, and 23.35 nM, respectively. CX-5279 free acid's inhibitory activity against PIM1 is very weak, with a IC50 value of 8.52 μM. CX-5279 free acid exhibits anti-proliferative activity in various cancer cell lines. CX-5279 free acid can be used for research on cancers such as pancreatic cancer and leukemia .
Cat. No.: HY-184863
CAS No.: 1034617-66-7
Target:
Research Areas:
PLK1-IN-17 is a potent PLK1 inhibitor with an IC50 of 2 nM. PLK1-IN-17 shows high selectivity for PLK2 and CDK2/A, moderate selectivity for PLK3, only weak activity against CK2, FLT3 and NEK6, and no activity against PDGFR, ALK and another 37 kinases. PLK1-IN-17 inhibits the proliferation of ovarian cancer cells and can be used in ovarian cancer-related research .
Cat. No.: HY-RS28358
Target:
Research Areas:
Csnk2b Rat Pre-designed siRNA Set A contains three designed siRNAs for Csnk2b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P76296
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CSNK2A2; Casein Kinase 2 Alpha'; Casein Kinase 2 Alpha 2; CK II Alpha'; CK2alpha'; CK2A2; CSNK2A1; Non-Specific Serine/Threonine Protein Kinase; Casein Kinase 2, Alpha Prime Polypeptide; Casein Kinase II Subunit Alpha; Casein Kinase II Subunit Alpha'; CK
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P76297
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CSNK2A2; Casein Kinase 2 Alpha'; Casein Kinase 2 Alpha 2; CK II Alpha'; CK2alpha'; CK2A2; CSNK2A1; Non-Specific Serine/Threonine Protein Kinase; Casein Kinase 2, Alpha Prime Polypeptide; Casein Kinase II Subunit Alpha; Casein Kinase II Subunit Alpha'; CK II Alpha
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-RS17672
Target:
Research Areas:
Csnk2a1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Csnk2a1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-184414
Target:
Research Areas:
BMS-135-L-Lys is a dual-cation prodrug derived from CK2 inhibitor BMS-135 (HY-181022) through esterification with L-lysine using a secondary alcohol. BMS-135-L-Lys achieves enhanced solubility by maintaining protonation of the ε-amino group of the Lys side chain at intestinal pH. BMS-135-L-Lys is released in situ by intestinal wall esterase from the parent drug, significantly increasing the oral bioavailability of the parent drug and overcoming the non-linear pharmacokinetic problem when the dose of the parent drug is increased. BMS-135-L-Lys can be used in related research on colon cancer and lung cancer .
Cat. No.: HY-184414A
Target:
Research Areas:
BMS-135-L-Lys TFA is a dual-cation prodrug derived from CK2 inhibitor BMS-135 (HY-181022) through esterification with L-lysine using a secondary alcohol. BMS-135-L-Lys TFA achieves enhanced solubility by maintaining protonation of the ε-amino group of the Lys side chain at intestinal pH. BMS-135-L-Lys TFA is released in situ by intestinal wall esterase from the parent drug, significantly increasing the oral bioavailability of the parent drug and overcoming the non-linear pharmacokinetic problem when the dose of the parent drug is increased. BMS-135-L-Lys TFA can be used in related research on colon cancer and lung cancer .
Cat. No.: HY-184414B
Target:
Research Areas:
BMS-135-L-Lys dihydrochloride is a dual-cation prodrug derived from CK2 inhibitor BMS-135 (HY-181022) through esterification with L-lysine using a secondary alcohol. BMS-135-L-Lys dihydrochloride achieves enhanced solubility by maintaining protonation of the ε-amino group of the Lys side chain at intestinal pH. BMS-135-L-Lys dihydrochloride is released in situ by intestinal wall esterase from the parent drug, significantly increasing the oral bioavailability of the parent drug and overcoming the non-linear pharmacokinetic problem when the dose of the parent drug is increased. BMS-135-L-Lys dihydrochloride can be used in related research on colon cancer and lung cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
