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Cat. No.: HY-163801

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Nurr1 agonist 9

Name: Nurr1 agonist 9
Brand: MedChemExpress
SKU: HY-163801
Availability: PreOrder

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

Nurr1 agonist 9 (Compound 36) is an agonist for Nurr1 with an EC₅₀ of 0.090 µM and a K_d of 0.17 µM. Nurr1 agonist 9 activates the Nurr1 homodimer (NurRE, EC₅₀=0.094 µM) and the Nurr1-RXR heterodimer (DR5, EC₅₀=0.165 µM). Nurr1 agonist 9 induces the expression of Nurr1-regulated tyrosine hydroxylase (TH) in organoid Parkinson's Disease model. Nurr1 agonist 9 is human brain endothelial cell barrier prmeable.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₁H₁₉ClN₄O₂
분자량:394.85

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Nurr1 agonist 9 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
Publications (1)
순도&문서
References
Calculators
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Bioz

Biological Activity

제품 설명

IC₅₀ & Target

Nurr1/NR4A2

0.09 μM (EC₅₀)

Nurr1/NR4A2

0.17 μM (Ki)

All Nuclear Hormone Receptor 4A/NR4A Isoforms :

Chemical Information

분자량 394.85
화학식 C₂₁H₁₉ClN₄O₂
SMILES

CC1=C(NC(C2=CC=C(C3=CC=C(N(C)C)C=C3)O2)=O)N(C=CC=C4Cl)C4=N1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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J Med Chem

Comparative Profiling and Chemogenomics Application of Chemical Tools for NR4A Nuclear Receptors. [Abstract]

2025 Oct 9;68(19):19955-19970. PMID: 40968635

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sai M, et al., Development of Nurr1 agonists from amodiaquine by scaffold hopping and fragment growing. Commun Chem. 2024 Jun 29;7(1):149. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Nurr1 agonist 9

1 Cited Publications

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
Publications (1)
순도&문서
References

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Nurr1 agonist 9

Publications Citing Use of MedChemExpress (MCE) Nurr1 agonist 9

All Nuclear Hormone Receptor 4A/NR4A Isoforms