Nurr1 agonist 9
Based on 1 publication(s) in Google Scholar
Nurr1 agonist 9 (Compound 36) is an agonist for Nurr1 with an EC50 of 0.090 µM and a Kd of 0.17 µM. Nurr1 agonist 9 activates the Nurr1 homodimer (NurRE, EC50=0.094 µM) and the Nurr1-RXR heterodimer (DR5, EC50=0.165 µM). Nurr1 agonist 9 induces the expression of Nurr1-regulated tyrosine hydroxylase (TH) in organoid Parkinson's Disease model. Nurr1 agonist 9 is human brain endothelial cell barrier prmeable.
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- Formule: C21H19ClN4O2
- Masse moléculaire:394.85
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Stockage:
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Publications Citing Use of MedChemExpress (MCE) Nurr1 agonist 9
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Activité biologique
Description
IC50 & Target
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Nurr1/NR4A2 0.09 μM (EC50) |
Nurr1/NR4A2 0.17 μM (Ki) |
Chemical Information
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Masse moléculaire 394.85
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Formule C21H19ClN4O2
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SMILES
CC1=C(NC(C2=CC=C(C3=CC=C(N(C)C)C=C3)O2)=O)N(C=CC=C4Cl)C4=N1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Med Chem
Comparative Profiling and Chemogenomics Application of Chemical Tools for NR4A Nuclear Receptors. [Abstract]2025 Oct 9;68(19):19955-19970. PMID: 40968635
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nurr1 agonist 9 Related Classifications
HY-163801 Related Classifications
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