Omodenbamab
Based on 1 Customer Validation
Omodenbamab is an anti-SpA (Staphylococcal protein A) human monoclonal antibody with a KD value of 0.0467 nM. Omodenbamab circumvents a key S. aureus evasion mechanism by targeting the cell wall moiety Protein A (SpA). Omodenbamab can be used in research of S. aureus bloodstream infection.
For research use only. We do not sell to patients.
- Purity: 96.77%
- CAS No.: 2241724-48-9
- Molecular Weight:156.08 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human IgG3 kappa
Human
staphylococcal protein A
Omodenbamab (514-G3) binds to S. aureus and leaves the Fc region exposed for FcγR1A receptor binding[1]. Omodenbamab (10 μg/mL; 30 min, 1.5 hr, and 2.5 hr) supports the opsonophagocytic killing of S. aureus by human blood cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/C mice with MRSA in a bacteremia model[1]
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Dosage:2.5 mg/mice and 10 mg/mice
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Administration:Intravenous injection
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Result:Increased mouse Balb/C mice with MRSA in a bacteremia model survival.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG3 kappa
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 2241724-48-9
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Appearance Liquid
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Molecular Weight 156.08 kDa
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Color Colorless to light yellow
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SMILES
[Omodenbamab]
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Synonyms
514-G3
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (259 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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