Isotope-Labeled Eicosanoids

Prostaglandin F1β-d₉ is deuterium labeled Prostaglandin F1β.

13,14-Dihydro-15-keto-PGE2-d₄ is the deuterium labeled 13,14-Dihydro-15-keto-PGE2.

Prostaglandin F1a-d₉ is the deuterium labeled Prostaglandin F1a. Prostaglandin F1a is an endogenous metabolite and a cyclooxygenase product with platelet activity inhibitory effects. Prostaglandin F1a can be used as a marker in coagulation-related studies.

PGD2 ethanolamide-d₄ is the deuterium labeled PGD2 ethanolamide.

15-Keto-prostaglandin E2-d₉ is the d₉ labeled 15-keto-Prostaglandin E2 (HY-113205). 15-keto-Prostaglandin E2 (15-keto-PGE2) is an endogenous PGE₂ metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to the Cys259 residue of STAT3. 15-keto-Prostaglandin E2 binds to and stabilizes EP2 and EP4 receptors. 15-keto-Prostaglandin E2 inhibits the growth and progression of breast cancer cells. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth. 15-keto-Prostaglandin E2 disrupts glomerular vascularization during zebrafish development and reduces the surface area of the glomerular filtration barrier.

(±)5-iPF2α-VI-d₁₁ is the deuterium labeled (±)5-iPF2α-VI.

Dinoprost-d₉ is the deuterium labeled Dinoprost. Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour.

2,3-Dinor-11β-prostaglandin F2α-d₉ is the deuterium labeled 2,3-Dinor-11β-prostaglandin F2α.

Prostaglandin B2-d₄ is the deuterium labeled Prostaglandin B2.

9α,11β-Prostaglandin F2α-d₉ is the deuterium labeled 9α,11β-Prostaglandin F2α.

9(S)-HETE-d₈ is the deuterium labeled 9(S)-HETE.

(±)15-HETE-d₈ is the deuterium labeled (±)15-HETE.

13,14-Dihydro PGE1-d₄ (13,14-Dihydroprostaglandin E1-d₄) is deuterium labeled 13,14-Dihydro PGE1. 13,14-Dihydro PGE₁ is a metabolite of PGE₁ (Prostaglandin E1) which inhibits the ADP-induced platelet aggregation (ID₅₀ = 10.8 ng/mL platelet rich plasma).

Prostaglandin E2-1-glyceryl ester-d₅ (PGE2-1-glyceyl ester-d₅) is deuterium labeled Prostaglandin E2-1-glyceryl ester. Prostaglandin E2-1-glyceryl ester, a Prostaglandin Glycerol Ester, is an endocannabinoid ligand for the CB₁ receptor. Prostaglandin E2-1-glyceryl ester induces rapid, transient elevation of intracellular free Ca²⁺.

11,12-DiHETrE-d₁₁ is the deuterium labeled 11,12-DiHETrE.

8-iso Prostaglandin F2α-d₉ is the deuterium labeled 8-Isoprostaglandin F2α. 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.

Prostaglandin E1-d₄ is the deuterium labeled Prostaglandin E1. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases.

Prostaglandin E2 Ethanolamide-d4 (PGE2 ethanolamide-d4) is the deuterium labeled Prostaglandin E2 Ethanolamide (HY-121996).

Tetranor-PGDM-d₆ is the deuterium labeled Tetranor-PGDM.

Prostaglandin A2-d₄ is the deuterium labeled Prostaglandin A2.