PAR 4 (1-6) (human)
PAR 4 (1-6) human, a hexapeptide, is a fragment of protease-activated receptor 4 (PAR4). PAR 4 (1-6) TFA acts as a PAR4-specific agonist.
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- CAS. Nr.: 225779-44-2
- Formel: C28H41N7O9
- Molecular Weight:619.67
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
PAR 4 (1-6) (GYPGQV) stimulats [3H]-thymidine incorporation in SMC. At 500 μM, the peptide increases DNA synthesis 2.5 fold above controls. A comparable mitogenic effect is obtained after stimulation of the SMC by 10 nM thrombin or 100 μM SFLLRN, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 225779-44-2
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Molecular Weight 619.67
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Formel C28H41N7O9
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Synonyms
GYPGQV
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Sequence
Gly-Tyr-Pro-Gly-Gln-Val
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Sequence Shortening
GYPGQV
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. H Andersen, et al. Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11189-93. [Content Brief]
[2]. E Bretschneider, et al. Evidence for functionally active protease-activated receptor-4 (PAR-4) in human vascular smooth muscle cells. Br J Pharmacol. 2001 Apr;132(7):1441-6. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PAR 4 (1-6) (human) Related Classifications
HY-P1313 Related Classifications
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