PBZ1038

Cat. No.: HY-163887 Purity: 98.57%: Data Sheet
COA

SDS
Handling Instructions
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PBZ1038 is a highly effective inhibitor of Gram-negative chaperone proteins, achieving its antibacterial effect by inhibiting GroES/GroEL.

For research use only. We do not sell to patients.

PBZ1038 Chemical Structure

CAS No. : 2043687-46-1

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Description

PBZ1038 is a highly effective inhibitor of Gram-negative chaperone proteins, achieving its antibacterial effect by inhibiting GroES/GroEL^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	38 μM Compound: 2h-p	Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by alamar blue assay Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by alamar blue assay	[PMID: 27720295]

Molecular Weight

537.56

Formula

C₂₅H₁₉N₃O₇S₂

CAS No.

2043687-46-1

Appearance

Solid

Color

White to off-white

SMILES

O=S(NC1=CC=C(C2=NC3=CC(NS(=O)(C4=CC=C(C=C4)O)=O)=CC=C3O2)C=C1)(C5=CC=C(C=C5)O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (93.01 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8603 mL	9.3013 mL	18.6026 mL
5 mM	0.3721 mL	1.8603 mL	3.7205 mL
10 mM	0.1860 mL	0.9301 mL	1.8603 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.57%

Select Batch:

Data Sheet (267 KB) SDS (252 KB)

COA (247 KB) HNMR (132 KB) RP-HPLC (160 KB) LCMS (381 KB)

Handling Instructions (2659 KB)

References

[1]. Godek J, et al. Bis-sulfonamido-2-phenylbenzoxazoles Validate the GroES/EL Chaperone System as a Viable Antibiotic Target[J]. Journal of the American Chemical Society, 2024. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8603 mL	9.3013 mL	18.6026 mL	46.5064 mL
	5 mM	0.3721 mL	1.8603 mL	3.7205 mL	9.3013 mL
	10 mM	0.1860 mL	0.9301 mL	1.8603 mL	4.6506 mL
	15 mM	0.1240 mL	0.6201 mL	1.2402 mL	3.1004 mL
	20 mM	0.0930 mL	0.4651 mL	0.9301 mL	2.3253 mL
	25 mM	0.0744 mL	0.3721 mL	0.7441 mL	1.8603 mL
	30 mM	0.0620 mL	0.3100 mL	0.6201 mL	1.5502 mL
	40 mM	0.0465 mL	0.2325 mL	0.4651 mL	1.1627 mL
	50 mM	0.0372 mL	0.1860 mL	0.3721 mL	0.9301 mL
	60 mM	0.0310 mL	0.1550 mL	0.3100 mL	0.7751 mL
	80 mM	0.0233 mL	0.1163 mL	0.2325 mL	0.5813 mL

PBZ1038 Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PBZ10382043687-46-1PBZ 1038PBZ-1038BacterialGram-negative chaperone proteinsGroES/GroELantibacterial activityInhibitorinhibitorinhibit

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PBZ1038

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