country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-145903

Copy Link Print Information

PDGFRα/FLT3-ITD-IN-2

PDGFRα/FLT3-ITD-IN-2 (Compound 13d) is a potent inhibitor of PDGFRα/FLT3 with IC₅₀s of more than 20 and 1.654 μM, respectively. PDGFRα/FLT3-ITD-IN-2 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia.

For research use only. We do not sell to patients.

CAS No.: 2761259-09-8
Formula: C₂₈H₄₁N₉O
Molecular Weight:519.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

PDGFRα/FLT3-ITD-IN-2 Chemical Structure

CAS No.: 2761259-09-8

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All PDGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
EOL1	GI₅₀	0.676 μM Compound: 13d	Antiproliferative activity against human EOL1 cells expressing IP1L1-PDGFRA fusion protein Antiproliferative activity against human EOL1 cells expressing IP1L1-PDGFRA fusion protein	[PMID: 35124201]
K562	GI₅₀	8.256 μM Compound: 13d	Antiproliferative activity against human K562 cells Antiproliferative activity against human K562 cells	[PMID: 35124201]
Kasumi 1	GI₅₀	2.559 μM Compound: 13d	Antiproliferative activity against human Kasumi 1 cells harboring N822K KIT mutant Antiproliferative activity against human Kasumi 1 cells harboring N822K KIT mutant	[PMID: 35124201]
MV4-11	GI₅₀	0.577 μM Compound: 13d	Antiproliferative activity against human MV4-11 cells expressing FLT3-ITD mutant Antiproliferative activity against human MV4-11 cells expressing FLT3-ITD mutant	[PMID: 35124201]

Chemical Information

CAS No. 2761259-09-8
Molecular Weight 519.68
Formula C₂₈H₄₁N₉O
SMILES

NCCCCNC(C1=CC=C(C=C1)CNC2=NC(N[C@H]3CC[C@@H](CC3)N)=NC4=C2N=CN4C5CCCC5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vlková K, et al. Synthesis and biological activity evaluation of novel 2,6,9-trisubstituted purine conjugates as potential protein kinases inhibitors. Bioorg Med Chem Lett. 2022 Mar 15;60:128603 [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

PDGFRα/FLT3-ITD-IN-2

All PDGFR Isoforms