2. Immunology/Inflammation
  3. Aryl Hydrocarbon Receptor
  4. Penisimplicissin

Penisimplicissin is a funicone-like compound and antiviral agent. Penisimplicissin reduces the expression of AhR and viral nucleocapsid protein. Penisimplicissin improves the cell viability and morphological characteristics of CCoV-infected cells. Penisimplicissin inhibits CCoV infection. Penisimplicissin can be used in studies related to canine coronavirus infection.

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Penisimplicissin

Penisimplicissin Chemical Structure

CAS No. : 873207-55-7

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Penisimplicissin Related Antibodies

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Description

Penisimplicissin is a funicone-like compound and antiviral agent. Penisimplicissin reduces the expression of AhR and viral nucleocapsid protein. Penisimplicissin improves the cell viability and morphological characteristics of CCoV-infected cells. Penisimplicissin inhibits CCoV infection. Penisimplicissin can be used in studies related to canine coronavirus infection[1].

In Vitro

Penisimplicissin (0.1-10 μM; 48 h) exhibits an IC50 of 4.9562 μM in canine fibrosarcoma A72 cells[1].
Penisimplicissin (0.1-2.5 μM; 48 h) significantly increases the cell viability of canine fibrosarcoma A72 cells infected with canine coronavirus (CCoV) after 48 h of treatment at concentrations of 0.5 μM and 2.5 μM[1].
Penisimplicissin (0.5 μM) reduces the morphological features of cell death in canine fibrosarcoma A72 cells infected with canine coronavirus (CCoV), including cell shrinkage, pyknosis, and cell detachment[1].
Penisimplicissin (0.5 μM; 48 h post-infection) significantly reduces viral yield and cytopathic effect in CCoV-infected canine fibrosarcoma A72 cells at 48 h post-treatment[1].
Penisimplicissin (0.5 μM; 24 h) significantly reduces the expression of aryl hydrocarbon receptor and viral nucleocapsid protein in both uninfected and CCoV-infected canine fibrosarcoma A72 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Penisimplicissin Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: canine fibrosarcoma A72 cells
Concentration: 0.1 μM, 0.5 μM, 1 μM, 2.5 μM, 5 μM, 10 μM
Incubation Time: 48 h
Result: Showed no significant difference in cell viability compared to vehicle control at 0.1, 0.5, and 2.5 μM (p > 0.05).
Significantly reduced cell viability at 1 μM (p < 0.05), 5 μM (p < 0.01), and 10 μM (p < 0.001).
Determined an IC50 of 4.9562 μM in A72 cells.

Cell Viability Assay[1]

Cell Line: canine fibrosarcoma A72 cells infected with canine coronavirus (CCoV)
Concentration: 0.1 μM, 0.5 μM, 2.5 μM
Incubation Time: 48 h post-infection
Result: Showed no significant change in cell viability compared to untreated infected cells at 0.1 μM (p > 0.05).
Significantly increased cell viability in CCoV-infected A72 cells at 0.5 μM (p < 0.01) and 2.5 μM (p < 0.05).
Led to selection of the 0.5 μM dose for subsequent experiments.

Real Time qPCR[1]

Cell Line: canine fibrosarcoma A72 cells infected with CCoV
Concentration: 0.5 μM
Incubation Time: 48 h post-infection
Result: Caused a significant (p < 0.05) decrease in CCoV titer, measured as Log TCID50/mL, compared to untreated infected cells.
Resulted in a decreased cytopathic effect in treated cells relative to untreated infected cells.

Immunofluorescence[1]

Cell Line: canine fibrosarcoma A72 cells (uninfected and CCoV-infected)
Concentration: 0.5 μM
Incubation Time: 24 h post-treatment (uninfected cells); 24 h post-infection (infected cells)
Result: Caused a significant (p < 0.001) reduction in AhR expression in uninfected A72 cells compared to vehicle control.
Resulted in significant reductions in both AhR (p < 0.001) and viral NP (p < 0.001) expression in CCoV-infected A72 cells compared to untreated infected cells.
Molecular Weight

302.28

Formula

C16H14O6
CAS No.
SMILES

COC1=C2[C@H](C3=COC(C)=CC3=O)OC(C2=CC(OC)=C1)=O
Structure Classification
Initial Source

Talaromyces pinophilus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Penisimplicissin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Penisimplicissin873207-55-7Aryl Hydrocarbon ReceptorAhRlysosomeviral nucleocapsid proteinligand-activated transcription factorscanine coronavirusaryl hydrocarbon receptorlysosomal alkalinizationcanine fibrosarcoma A72 cellscell viabilitycytopathic effectcytoprotective agentInhibitorinhibitorinhibit

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