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Cat. No.: HY-N21615

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Phaeocaulisin M

Phaeocaulisin M is a guaiane-type sesquiterpene containing a novel 1,2-dioxolane-3-ol structure. Phaeocaulisin M inhibits LPS (HY-D1056)-induced nitric oxide (NO) production in RAW 264.7 macrophages with an IC₅₀ of 6.05 μM, and shows no significant cytotoxicity at the effective concentrations for inhibiting NO production. Phaeocaulisin M is found in the rhizomes of Curcuma phaeocaulis and can be used for research related to inflammatory responses.

For research use only. We do not sell to patients.

CAS No.: 1966155-64-5
Formula: C₁₅H₂₄O₅
Molecular Weight:284.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Phaeocaulisin M Chemical Structure

CAS No.: 1966155-64-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

All NO Synthase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC50	6.05 μM	Inhibition of lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages incubated for 24 h, measured by Griess reagent assay of nitrite concentration in cell supernatant. Inhibition of lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages incubated for 24 h, measured by Griess reagent assay of nitrite concentration in cell supernatant.	10286020.2015.1046449

In Vitro

Phaeocaulisin M (compound 3) (1 μg/mL LPS; 24 h) inhibits LPS-induced NO production in RAW 264.7 macrophages with an IC₅₀ of 6.05 μM and exhibits no significant cytotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1966155-64-5
Molecular Weight 284.35
Formula C₁₅H₂₄O₅
SMILES

OC12C(C(C)(OO2)C)=C[C@@]3([H])[C@](CC[C@@]3(O)C)([H])[C@@](O)(C1)C
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ma JH, et al. Four new sesquiterpenes from the rhizomes of Curcuma phaeocaulis and their iNOS inhibitory activities. J Asian Nat Prod Res. 2015;17(5):532-540.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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