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  3. Fluorescent Dye
  4. PNE-Lyso

PNE-Lyso is a activatable fluorescent probe. PNE-Lyso can be used to detect intracellular pH and hexosaminidases with two kinds of fluorescence signals. PNE-Lyso can be used to distinguish apoptosis from necrosis through visualizing lysosome morphology. PNE-Lyso is capable of investigating the agent-induced cell death process.

For research use only. We do not sell to patients.

PNE-Lyso Chemical Structure

PNE-Lyso Chemical Structure

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PNE-Lyso Related Antibodies

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Description

PNE-Lyso is a activatable fluorescent probe. PNE-Lyso can be used to detect intracellular pH and hexosaminidases with two kinds of fluorescence signals. PNE-Lyso can be used to distinguish apoptosis from necrosis through visualizing lysosome morphology. PNE-Lyso is capable of investigating the agent-induced cell death process[1].

In Vitro

PNE-Lyso exhibits a strong UV-vis absorption peak at 420 nm in alkaline solution[1].
When PNE-Lyso was treated with Hexs, the fluorescence intensity at 635 nm decreased and blue-shifted (λex = 530 nm), and a new remarkable fluorescence emission at 520 nm appeared (λex = 460 nm), displaying a ratiometric fluorescence signal[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PNE-Lyso Related Antibodies
Molecular Weight

506.55

Formula

C28H30N2O7
SMILES

OCC1OC(OC2=CC3=C(C=C4C(O3)=C(CCC4)/C=C/C5=CC=NC=C5)C=C2)C(NC(C)=O)C(O)C1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PNE-Lyso Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PNE-LysoFluorescent DyeHK-2 cellsfluorescent probeapoptosisnecrosislysosomehexosaminidaseInhibitorinhibitorinhibit

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HY-151544
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