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Cat. No.: HY-145840

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Pol I-IN-1

Pol I-IN-1 is a potent RNA polymerase I (Pol I) inhibitor with IC₅₀ 0.21 µM for the Pol I large catalytic subunit RPA194.

For research use only. We do not sell to patients.

CAS No.: 2765318-69-0
Formula: C₂₃H₂₂N₄O₂
Molecular Weight:386.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Pol I-IN-1 Chemical Structure

CAS No.: 2765318-69-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Pol I-IN-1 is a potent RNA polymerase I (Pol I) inhibitor with IC₅₀ 0.21 µM for the Pol I large catalytic subunit RPA194^[1].

IC₅₀ & Target

RNA Polymerase

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	38 nM Compound: 31	Cytotoxicity against human A-375 cells assessed as reduction in cell viability incubated for 72 hrs by cell titer glo luminescent assay Cytotoxicity against human A-375 cells assessed as reduction in cell viability incubated for 72 hrs by cell titer glo luminescent assay	[PMID: 35450366]

Chemical Information

CAS No. 2765318-69-0
Molecular Weight 386.45
Formula C₂₃H₂₂N₄O₂
SMILES

O=C(C1=CC=CN2C(C3=C(C4=C(C=C3)C=CC=C4)N=C12)=O)NCCN5CCCC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tony E. Dorado et al. Discovery and Evaluation of Novel Angular Fused Pyridoquinazolinonecarboxamides as RNA Polymerase I Inhibitors. ACS Medicinal Chemistry Letters 2022 13 (4), 608-614

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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