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Cat. No.: HY-146441

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Prohibitin ligand 1

Prohibitin ligand 1 (Compound 22i), a cardioprotectant prohibitin ligand, induces a phosphorylation of the pro-survival factor STAT3. Prohibitin ligand 1 exhibits in vitro cardioprotectant activities at nanomolar concentrations.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₀H₂₂N₂O
분자량:306.40

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Prohibitin ligand 1 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
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Biological Activity

제품 설명

All STAT Isoforms :

In Vitro

Prohibitin ligand 1 (10nM; overnight) treatment induces phosphorylation of the pro-survival factor STAT3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

H9c2 cardiomyocyte
Concentration:

10 nM
Incubation Time:

overnight
Result:

Induced a phosphorylation of the pro-survival factor STAT3.

Chemical Information

분자량 306.40
화학식 C₂₀H₂₂N₂O
SMILES

CC(N1CC[C@]2([C@@H]1C3=CC=CC=C3)C(NC4=CC=CC=C42)=O)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Sabria Elderwish, et al. Discovery of 3,3'-pyrrolidinyl-spirooxindoles as cardioprotectant prohibitin ligands. Eur J Med Chem. 2020 Jan 15;186:111859. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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Prohibitin ligand 1

All STAT Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Prohibitin ligand 1 Related Classifications

HY-146441 Related Classifications