Propargyl-PEG3-phosphonic acid
Based on 1 Customer Validation
Propargyl-PEG3-phosphonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG3-phosphonic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity : 99.51%
- CAS No.: 1714139-62-4
- Formula: C9H17O6P
- Molecular Weight:252.20
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
PEGs |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1714139-62-4
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Appearance Liquid
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Molecular Weight 252.20
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Formula C9H17O6P
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Color Light yellow to brown
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SMILES
OP(O)(CCOCCOCCOCC#C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : ≥ 125 mg/mL (495.64 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (269 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9651 mL | 19.8255 mL | 39.6511 mL | 99.1277 mL |
| 5 mM | 0.7930 mL | 3.9651 mL | 7.9302 mL | 19.8255 mL | |
| 10 mM | 0.3965 mL | 1.9826 mL | 3.9651 mL | 9.9128 mL | |
| 15 mM | 0.2643 mL | 1.3217 mL | 2.6434 mL | 6.6085 mL | |
| 20 mM | 0.1983 mL | 0.9913 mL | 1.9826 mL | 4.9564 mL | |
| 25 mM | 0.1586 mL | 0.7930 mL | 1.5860 mL | 3.9651 mL | |
| 30 mM | 0.1322 mL | 0.6609 mL | 1.3217 mL | 3.3043 mL | |
| 40 mM | 0.0991 mL | 0.4956 mL | 0.9913 mL | 2.4782 mL | |
| 50 mM | 0.0793 mL | 0.3965 mL | 0.7930 mL | 1.9826 mL | |
| 60 mM | 0.0661 mL | 0.3304 mL | 0.6609 mL | 1.6521 mL | |
| 80 mM | 0.0496 mL | 0.2478 mL | 0.4956 mL | 1.2391 mL | |
| 100 mM | 0.0397 mL | 0.1983 mL | 0.3965 mL | 0.9913 mL |
Propargyl-PEG3-phosphonic acid Related Classifications
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