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Art. -Nr.: HY-177694

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PROTAC AR Degrader-11

PROTAC AR Degrader-11 is a PROTAC degrader that targets the androgen receptor (AR) and its splice variant AR-V7. PROTAC AR Degrader-11 simultaneously degrades full-length AR and AR-V7 via the ubiquitin-proteasome system by recruiting the CRL4-CRBN E3 ligase (FIG.2A). PROTAC AR Degrader-11 reduces the viability of cancer cells. PROTAC AR Degrader-11 can be used in studies related to castration-resistant prostate cancer.
(Pink: Androgen Receptor ligand (HY-171809); Blue: Cereblon ligand (HY-A0003); Black: linker (HY-169966)).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2798907-41-0
Formel: C₃₆H₃₉F₃N₈O₆
Molecular Weight:736.74

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

PROTAC AR Degrader-11 Chemical Structure

CAS. Nr.: 2798907-41-0

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Preis

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Menge

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

PROTAC AR Degrader-11 is a PROTAC degrader that targets the androgen receptor (AR) and its splice variant AR-V7. PROTAC AR Degrader-11 simultaneously degrades full-length AR and AR-V7 via the ubiquitin-proteasome system by recruiting the CRL4-CRBN E3 ligase (FIG.2A). PROTAC AR Degrader-11 reduces the viability of cancer cells. PROTAC AR Degrader-11 can be used in studies related to castration-resistant prostate cancer^[1]. (Pink: Androgen Receptor ligand (HY-171809); Blue: Cereblon ligand (HY-A0003); Black: linker (HY-169966)).

IC₅₀ & Target

^[1]

AR-V7

Alle PROTACs Isoform-spezifische Produkte anzeigen :

In Vitro

PROTAC AR Degrader-11 (Compound 30) (10-10000 nM; 3-7 days) reduces the viability of castration-resistant prostate cancer cells expressing androgen receptor/AR-V7 in a concentration- and time-dependent manner^[1].
PROTAC AR Degrader-11 reduces full-length AR and AR-V7 protein levels in a concentration-dependent manner in CWR22RV1 (AR-V7 high-expression) and VCaP (AR-amplified) cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

castration-resistant prostate cancer cells expressing androgen receptor/AR-V7
Concentration:

10, 100, 1000 and 10000 nM
Incubation Time:

3 days; 7 days
Result:

Resulted in ~110% cell viability at 10 nM, ~52% at 100 nM, ~27% at 1000 nM, and ~20% at 10000 nM after 3 days incubation.
Resulted in ~102% cell viability at 10 nM, ~32% at 100 nM, ~3% at 1000 nM, and ~2% at 10000 nM after 7 days incubation.

Related Protocols :

Chemical Information

CAS. Nr. 2798907-41-0
Molecular Weight 736.74
Formel C₃₆H₃₉F₃N₈O₆
SMILES

O=C(COCCCCOC1=CC=C(C2CCN(CC2)C3=NN4C(CC3)=NN=C4C(F)(F)F)C=C1)NC5=CC=CC6=C5CN(C7C(NC(CC7)=O)=O)C6=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chih-Wei Fu, et al. Androgen receptor binding bifunctional molecules. EP4023649A1. 2021-12-23

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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