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Cat. No.: HY-177694

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PROTAC AR Degrader-11

PROTAC AR Degrader-11 is a potent androgen receptor and androgen receptor splice variant-7 PROTAC degrader. PROTAC AR Degrader-11 shows potent cytotoxicity against both CWR22RV1 cells and VCaP cells. PROTAC AR Degrader-11 can be used in prostate cancer research.
(Pink: Androgen Receptor ligand (HY-171809); Blue: Cereblon ligand (HY-A0003); Black: linker (HY-169966)).

For research use only. We do not sell to patients.

CAS No.: 2798907-41-0
Formula: C₃₆H₃₉F₃N₈O₆
Molecular Weight:736.74

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

PROTAC AR Degrader-11 Chemical Structure

CAS No.: 2798907-41-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PROTAC AR Degrader-11 is a potent androgen receptor and androgen receptor splice variant-7 PROTAC degrader. PROTAC AR Degrader-11 shows potent cytotoxicity against both CWR22RV1 cells and VCaP cells. PROTAC AR Degrader-11 can be used in prostate cancer research^[1]. (Pink: Androgen Receptor ligand (HY-171809); Blue: Cereblon ligand (HY-A0003); Black: linker (HY-169966)).

All PROTACs Isoforms :

Chemical Information

CAS No. 2798907-41-0
Molecular Weight 736.74
Formula C₃₆H₃₉F₃N₈O₆
SMILES

O=C(COCCCCOC1=CC=C(C2CCN(CC2)C3=NN4C(CC3)=NN=C4C(F)(F)F)C=C1)NC5=CC=CC6=C5CN(C7C(NC(CC7)=O)=O)C6=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chih-Wei Fu, et al. Androgen receptor binding bifunctional molecules. EP4023649A1. 2021-12-23

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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PROTAC AR Degrader-11

All PROTACs Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC AR Degrader-11 Related Classifications

HY-177694 Related Classifications