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Cat. No.: HY-159947

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PROTAC BTK Degrader-11

PROTAC BTK Degrader-11 is a PROTAC degrader that can break down BTK, with a DC₅₀ of 1.7 nM. PROTAC BTK Degrader-11 can be used in cancer research.
(Pink: Btk ligand (HY-159956); Blue: Cereblon ligand (HY-150839); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 2736508-94-2
Formula: C₄₈H₅₅N₁₁O₄
Molecular Weight:850.02

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

PROTAC BTK Degrader-11 Chemical Structure

CAS No.: 2736508-94-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PROTAC BTK Degrader-11 is a PROTAC degrader that can break down BTK, with a DC₅₀ of 1.7 nM. PROTAC BTK Degrader-11 can be used in cancer research^[1]. (Pink: Btk ligand (HY-159956); Blue: Cereblon ligand (HY-150839); Black: linker).

All PROTACs Isoforms :

Chemical Information

CAS No. 2736508-94-2
Molecular Weight 850.02
Formula C₄₈H₅₅N₁₁O₄
SMILES

CC1=C([C@@H](C)NC(C2=NC(C(C)(C)C)=NO2)=O)C=CC(C3=C4C(NC(C5=CN=C(N6CCN(CC6)CC7CCN(C8=CC=C(C9C(NC(CC9)=O)=O)C=C8)CC7)C=C5)=C4)=NC=N3)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Haitao Wang, et al. BGB-16673, A BTK Degrader, Overcomes On-Target Resistance From BTK Inhibitors And Present. FRANKFURT VIRTUAL. 2023. P1219.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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