AURKB/AurB
Aurora B is the enzymatic core of the chromosomal passenger complex, in which it partners with INCENP, survivin and borealin to travel from chromosome arms in early mitosis to inner centromeres and then to the central spindle. It phosphorylates histone H3 and multiple kinetochore substrates to destabilize erroneous microtubule attachments, enforcing the fidelity requirements of the spindle assembly checkpoint, and it is required for cytokinesis. AURKB overexpression is common in tumors and correlates with aneuploidy, and selective inhibitors such as barasertib have been tested in acute myeloid leukemia, underscoring its mitosis-specific therapeutic appeal.
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AURKB/AurB Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
