CDK11B/CDC2L1
CDK11B, also called CDC2L1, is the better-characterized of the two tandem CDK11 genes on chromosome 1p36 and encodes the p110 and p58 PITSLRE kinase forms. During apoptosis, p110 is cleaved by caspase-1 to generate p58, which accumulates at centrosomes and contributes to apoptotic dismantling of the cell, linking CDK11B to both cell-cycle and death signaling. With cyclin L partners, CDK11B regulates transcription, RNA splicing, sister chromatid cohesion and autophagy. CDK11B is broadly expressed and elevated in several cancers, including multiple myeloma and hepatocellular carcinoma, making it an emerging therapeutic target distinct from classic proliferative CDKs.
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CDK11B/CDC2L1 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
