CDK12/CRK7
CDK12, once named CRK7, is a transcriptional cyclin-dependent kinase that pairs with cyclin K and phosphorylates Ser2 of the RNA polymerase II C-terminal domain to drive elongation of long, complex genes. It is particularly required for expression of DNA damage response genes, and CDK12-mutant prostate cancers show genomic instability with an inflamed tumor microenvironment. Biallelic germline CDK12 variants cause a neurodevelopmental syndrome with intellectual disability and dysmorphic features. Its C-terminal RS-rich domain connects it to splicing regulation. CDK12, together with the paralog CDK13, defines a branch of transcriptional CDKs distinct from cell-cycle CDK1-6 and from CDK8/9.
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CDK12/CRK7 Recombinant Proteins (6)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
