ERK7/MAPK15
ERK7 (MAPK15) is the most recently described classical MAPK-family kinase and behaves unlike its relatives: it is constitutively active, is not stimulated by known MAP2Ks or by stress, and requires its extended C-terminal tail for catalytic activity. Autophosphorylation of the activation-segment TEY motif maintains basal signaling. ERK7 concentrates at the base of primary cilia and regulates ciliogenesis and ciliary disassembly, linking it to Hedgehog signaling, and it has been implicated in autophagy and in secretory pathway function. Its expression is broad but low. Recombinant ERK7 is used for ciliary-signaling research and for filling gaps in MAPK-family inhibitor selectivity panels.
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ERK7/MAPK15 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
