IFN-alpha 13

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IFN-alpha 13 (IFNA13; IFN-α13) is produced by the macrophages, belongs to the alpha/beta interferon (IFN) family, a family of cytokines induced by viral infection and are primarily involved in antiviral defense of the cells^[1]. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively^[2]. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia^[3].
IFN-alpha13 exhibits acid-stable antiviral activity against Theiler's virus, Mengo virus, and vesicular stomatitis virus. Firstly, it is transcribed constitutively, independent of viral infection and of interferon regulatory factor-7 induction. Secondly, it contains two N-glycosylation sites, in contrast to other murine IFN-alpha subtypes that contain either one or no N-glycosylation site^[4]. As for a wildly use of IFN in animal model, the sequence of amino acids in IFNA13 protein of human is very different from mouse (64.55%).

References:

[1]. Kumagai Y, et al. Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses. Immunity. 2007 Aug;27(2):240-52. [Content Brief]

[2]. Zhang SY, et al. Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense. Immunol Rev. 2008 Dec;226:29-40. [Content Brief]

[3]. Raj NB, et al. Identification of a novel virus-responsive sequence in the promoter of murine interferon-alpha genes. J Biol Chem. 1991 Jun 15;266(17):11360-5. [Content Brief]

[4]. van Pesch V, et al. Characterization of interferon-alpha 13, a novel constitutive murine interferon-alpha subtype. J Biol Chem. 2003 Nov 21;278(47):46321-8. [Content Brief]

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IFN-alpha 13 Recombinant Proteins (8)

Species:	Human (2) Rhesus Macaque (1) Mouse (3) Cynomolgus (2)
Tag:	His (5) Fc (2) Tag Free (1)
Source:	E. coli (2) HEK293 (4) P. pastoris (2)

Cat. No.	Product Name / Synonyms	Species	Source

HY-P72796

IFN-alpha 13/IFNA1 Protein, Human Interferon alpha-1/13; IFN-alpha-1/13; LeIF D; IFNA1; IFNA13	Human	E. coli
IFN-alpha 13 (IFNA13), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 13/IFNA1 Protein, Human contains 166 a.a. (C24-D189), produced in E. coli cells with tag free.

HY-P700089AF

Animal-Free IFN-alpha 1a/IFNA1 Protein, Human (His) Leukocyte Interferon; IFNA1; B cell Interferon; Type I Interferon; Interferon alpha-1/13; IFN-alpha-1/13; LeIF D; IFNA1a; IFNA13	Human	E. coli
IFN-alpha 1a/IFNA1 Protein, produced by macrophages, demonstrates robust antiviral activities. It stimulates essential enzymes—a protein kinase and an oligoadenylate synthetase—contributing to the intricate molecular response that fortifies the host's immune defenses against viral threats. Animal-Free IFN-alpha 1a/IFNA1 Protein, Human (His) is the recombinant human-derived animal-FreeIFN-alpha 1a/IFNA1 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free IFN-alpha 1a/IFNA1 Protein, Human (His) is 166 a.a., with molecular weight of ~20.19 kDa.

HY-P73123

IFN-alpha 13/IFNA13 Protein, Cynomolgus (HEK293, His) Interferon alpha-13; IFN-alpha-13; LeIF D; IFNA13	Cynomolgus	HEK293
IFN-alpha 13 (IFNA13), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 13/IFNA13 Protein, Cynomolgus (HEK293, His) contains 166 a.a. (C25-E190), produced in HEK293 cells with a C-terminal His-tag.

HY-P73125

IFN-alpha 13/IFNA13 Protein, Mouse (HEK293, His) Interferon alpha-13; IFN-alpha-13; LeIF D; IFNA13	Mouse	HEK293
IFN-alpha 13 (IFNA13), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 13/IFNA13 Protein, Mouse (HEK293, His) contains 189 a.a. (M1-E189), produced in HEK293 cells with a C-terminal His-tag.

HY-P73124

IFN-alpha 13/IFNA13 Protein, Mouse (HEK293, Fc) Interferon alpha-13; IFN-alpha-13; LeIF D; IFNA13	Mouse	HEK293
IFN-alpha 13 (IFNA13), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 13/IFNA13 Protein, Mouse (HEK293, Fc) contains 166 a.a. (C24-E189), produced in HEK293 cells with a N-terminal hFc-tag.

HY-P73122

IFN-alpha 13/IFNA13 Protein, Cynomolgus (HEK293, Fc) Interferon alpha-13; IFN-alpha-13; LeIF D; IFNA13	Cynomolgus	HEK293
IFN-alpha 13 (IFNA13), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 13/IFNA13 Protein, Cynomolgus (HEK293, Fc) contains 166 a.a. (C25-E190), produced in HEK293 cells with a C-terminal hFc-tag.

HY-P73126

IFN-alpha 13/IFNA13 Protein, Rhesus (P.pastoris, His) Interferon alpha-13; IFN-alpha-13; LeIF D; IFNA13	Rhesus Macaque	P. pastoris
IFN-alpha 13 (IFNA13), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 13/IFNA13 Protein, Rhesus (P.pastoris, His) contains 166 a.a. (C25-E190), produced in P.pastoris yeast cells with a C-terminal His-tag.

HY-P73908

IFN-alpha 13/IFNA13 Protein, Mouse (P.pastoris, His) Interferon alpha13; IFN-alpha13; LeIF D; IFNA13	Mouse	P. pastoris
IFN-alpha 13 (IFNA13), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 13/IFNA13 Protein, Mouse (P.pastoris, His) contains 166 a.a. (C24-E189), produced in P.pastoris yeast cells with a C-terminal His-tag.

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IFN-alpha 13

IFN-alpha 13

Subscribe Now to the List of Recombinant Proteins

IFN-alpha 13 Recombinant Proteins (8)