IKKa/CHUK
IKKα, the product of the CHUK gene, is a catalytic subunit of the IκB kinase (IKK) complex together with IKKβ and the regulatory scaffold NEMO (IKKγ). Upon stimulation by TNF, IL-1 or pathogen-associated signals, IKKα contributes to phosphorylation of IκBα, marking it for ubiquitination and degradation and liberating NF-κB dimers for nuclear translocation. Relative to IKKβ, IKKα plays more prominent noncanonical roles: it phosphorylates NF-κB2 p100 during noncanonical NF-κB activation, controls keratinocyte proliferation and skin development, and shuttles to the nucleus to modulate histone H3 and transcriptional coactivator function. Recombinant IKKα supports studies of both canonical and alternative NF-κB signaling.
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IKKa/CHUK Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
