MAP3K2/MEKK2
MAP3K2 (MEKK2) is a STE11-family MAP3K that activates the JNK pathway through MKK4/MKK7 and also drives the MEK5-ERK5 cascade. Its regulation is unusual: MEKK2 activity is controlled by ubiquitination and by scaffold partners such as 14-3-3 proteins, and it transduces signals from lysophosphatidic acid receptors and DNA-damage responses. With its close paralog MEKK3 it contributes to vascular development and endothelial signaling; combined loss causes embryonic lethality with hemorrhagic phenotypes. MEKK2 additionally phosphorylates and activates LATS kinases, connecting it to Hippo-pathway regulation of YAP. Altered MAP3K2 expression has been reported in lung, ovarian and breast cancers.
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MAP3K2/MEKK2 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
