MAP3K3/MEKK3
MAP3K3 (MEKK3) signals predominantly through the MEK5-ERK5 module while also feeding the MKK3/6-p38 and MKK4/7-JNK cascades, positioning it as a hub of the STE11 group. MEKK3 is required for vascular integrity and placental development, and knockout embryos die in mid-gestation with defective angiogenesis and hemorrhage. It responds to TNF, lysophosphatidic acid, and osmotic and oxidative stress, and cooperates with 14-3-3 proteins and PB1-domain-containing partners for signal assembly. In immunity, MEKK3 governs B- and T-cell homeostasis and NF-κB activation downstream of antigen receptors. Amplification or dysregulation of MAP3K3 occurs in several cancers, and it is studied in hypertension and tumor angiogenesis.
-
MAP3K3/MEKK3 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
