MAP3K4/MEKK4
MAP3K4 (MEKK4, MTK1) is a large STE11-group MAP3K that activates both JNK and p38 via MKK4/7 and MKK3/6. MEKK4 is uniquely coupled to cytoskeletal dynamics: microtubule-depolymerizing agents and the GADD45-MEKK4 complex trigger its activation, and an N-terminal proline-rich region mediates interactions with cytoskeletal regulators. Beyond stress signaling, MEKK4 is essential in development, controlling testis determination and neural-tube closure in mice; mutations underlie the classic Small eye phenotype. In humans, MAP3K4 variants have been linked to disorders of sex development. Recombinant MEKK4 serves studies of GADD45-dependent activation and MAPK cross-talk with the cytoskeleton.
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MAP3K4/MEKK4 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
