MAPKAPK2/MK2
MAPKAPK2, commonly MK2, is the principal p38-activated protein kinase in inflammatory signaling. p38 alpha phosphorylates MK2 at activating sites, and MK2 then phosphorylates heat shock protein 27, tristetraprolin, and heterogeneous nuclear ribonucleoprotein A0, thereby increasing translation and stability of messenger RNAs encoding tumor necrosis factor alpha, interleukin-1, and interleukin-6. MK2 also controls cell migration through small heat shock protein phosphorylation and supports the DNA damage checkpoint after ultraviolet exposure. Genetic deletion protects mice from endotoxin shock and inflammatory arthritis. Because MK2 inhibitors reproduce many benefits of p38 blockade with reduced toxicity, they have been advanced toward treatment of inflammatory and autoimmune diseases.
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MAPKAPK2/MK2 Recombinant Proteins (5)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
