1. Cell Cycle/DNA Damage
  2. CDK
  3. [pSer2, pSer5, pSer7]-CTD TFA

[pSer2, pSer5, pSer7]-CTD TFA 

Cat. No.: HY-P1933A
Handling Instructions

[pSer2, pSer5, pSer7]-CTD (TFA), a substrate for CDK7 (cyclin dependent protein kinase), is a phosphorylated polypeptide at ser2, ser5 and ser7 sites of RNA polymerase II carboxy-terminal domain (CTD).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

[pSer2, pSer5, pSer7]-CTD TFA Chemical Structure

[pSer2, pSer5, pSer7]-CTD TFA Chemical Structure

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Other Forms of [pSer2, pSer5, pSer7]-CTD TFA:

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Description

[pSer2, pSer5, pSer7]-CTD (TFA), a substrate for CDK7 (cyclin dependent protein kinase), is a phosphorylated polypeptide at ser2, ser5 and ser7 sites of RNA polymerase II carboxy-terminal domain (CTD)[1].

Molecular Weight

2291.25

Formula

C₉₈H₁₃₈F₃N₂₁O₃₉

Sequence

{Tyr}{Ser}{Pro}{Thr}{Ser}{Pro}{Ser}{Tyr}{Ser}{Pro}{Thr}{Ser}{Pro}{Ser}{Tyr}{Ser}{Pro}{Thr}{Ser}{Pro}

Sequence Shortening

Y-{pSer}-PT-{pSer}-P-{pSer}-YSPTSPSYSPTSPS

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
[pSer2, pSer5, pSer7]-CTD TFA
Cat. No.:
HY-P1933A
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