PSMA-IN-1
PSMA-IN-1 (compound 23) is an inhibitor of PSMA with a Ki value of 2.49 nM. PSMA-IN-1 inhibits tumor growth with high selectivity and specificity in PSMA+ xenograft models. PSMA-IN-1 is a NIR probe (λEX: 620 nm; λEM: 670 nm) used for tumor disappearance. PSMA-IN-1 can be used for research on prostate cancer.
For research use only. We do not sell to patients.
- Formula: C66H80N10O20
- Molecular Weight:1333.40
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
PSMA-IN-1 (0.33 mg/kg, i.v., one time) inhibits tumor growth with high selectivity and specificity in the BALB/C nude mice tumor bearing model constructed with 22Rv1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:22Rv1 xenograft models in BALB/C nude mice[1]
-
Dosage:0.33 mg/kg
-
Administration:Intravenous injection (i.v.), sacrificed at 55 h post-injection
-
Result:Increased TNR (tumor-to-normal tissue ratio) values from 3.20 at 2 h to 6.27 at 48 h.
Chemical Information
-
Molecular Weight 1333.40
-
Formula C66H80N10O20
-
SMILES
OC(C1=O)=C(NC[C@H](NC(N[C@@H](CCCCNC(CCCCC[N+]2=C(C(C)(C3=C2C=CC=C3)C)/C=C4C([O-])=C(C\4=O)/C=C5C(C)(C6=C(N/5CCCCCC(NCCCC[C@H](NC(N[C@H](C(O)=O)CNC(C7=O)=C(C7=O)O)=O)C(O)=O)=O)C=CC=C6)C)=O)C(O)=O)=O)C(O)=O)C1=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PSMA-IN-1 Related Classifications
HY-149297 Related Classifications
Powered by Bioz