Substituted 7H-pyrido[4,3-c]carbazoles with potent anti-HIV activity

  • Bioorg Med Chem Lett. 1999 Jan 18;9(2):119-22. doi: 10.1016/s0960-894x(98)00708-2.
K Hirata  1 ,  C Ito ,  H Furukawa ,  M Itoigawa ,  L M Cosentino ,  K H Lee
Affiliations
  • 1. Faculty of Pharmacy, Meijo University, Nagoya, Japan.
PMID: 10021911 DOI: 10.1016/s0960-894x(98)00708-2
Abstract

Several substituted 7H-pyrido[4,3-c]carbazoles were synthesized from the natural product mukonal and tested for inhibition of HIV replication in H9 lymphocytes. 5-Methoxy-7-methyl-7H-pyrido[4,3-c]carbazole (7) had an EC50 value of 0.0054 microgram/mL and the highest therapeutic index (TI = 503) in the series.