Therapeutic effects of some cholinolytics in organophosphate intoxications

  • Arch Toxicol. 1976 Oct 28;36(2):139-46. doi: 10.1007/BF00351973.
J Faff ,  G Borkowska ,  W Bak
PMID: 1036888 DOI: 10.1007/BF00351973
Abstract

The therapeutic effects of pipethanate (sycotrol) and two newly synthetized cholinolytics, DPX-8 and ANC-51, were compared with atropine in mice poisoned by DDVP, fluostigmine, phospholine, and paraoxon. The antagonistic activotagonistic activity of tested drugs against acetylcholine-induced contraction of rat ileum and oxotremorine-induced salivation and tremor in the mouse was also studied. The anticholinergic activity of pipethanate, DPX-8, and ANC-51 was weaker than that of atropine. However,the therapeutic effect of pipethanate was higher than that of atropine in mice poisoned by the organophosphates. DPX-8 and ANC-51 afforded a better antidotal effect than atropine only in DDVP-poisoned mice.

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