The Importance of Drug Scheduling in Cancer Chemotherapy: Etoposide as an Example

  • Oncologist. 1996;1(4):234-239.
KR Hande  1
Affiliations
  • 1. Vanderbilt University School of Medicine, Medical Oncology, Nashville, Tennessee, 37232, USA.
PMID: 10387995
Abstract

Etoposide is a drug whose antineoplastic activity is dependent on the schedule of drug administration. This article reviews the rationale for a prolonged schedule of etoposide administration and the therapeutic results of use of such a schedule in the treatment of Cancer. The pharmacology of etoposide is also reviewed, with particular attention paid to the pharmacokinetics of oral etoposide and etoposide plasma concentrations associated with cytotoxicity.

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