Novel C-ring analogues of 20(S)-camptothecin-part-2: synthesis and in vitro cytotoxicity of 5-C-substituted 20(S)-camptothecin analogues

  • Bioorg Med Chem Lett. 1999 Jun 21;9(12):1633-8. doi: 10.1016/s0960-894x(99)00268-1.
D Subrahmanyam  1 ,  A Venkateswarlu ,  K Venkateswara Rao ,  T V Sastry ,  G Vandana ,  S A Kumar
Affiliations
  • 1. Natural Products Division, Dr. Reddy's Research Foundation, Miyapur, Hyderabad, India.
PMID: 10397491 DOI: 10.1016/s0960-894x(99)00268-1
Abstract

A series of 5-C-substituted 20(S)-camptothecin analogues were synthesised and evaluated their in vitro anti-cancer activity. Several of these analogues have showed excellent activity against human tumor cell lines.