Synthesis and antitumoral activities of marine ent-chromazonarol and related compounds

  • Bioorg Med Chem Lett. 1999 Aug 16;9(16):2325-8. doi: 10.1016/s0960-894x(99)00382-0.
A F Barrero  1 ,  E J Alvarez-Manzaneda ,  M M Herrador ,  R Chahboun ,  P Galera
Affiliations
  • 1. Instituto de Biotecnologia, Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Granada, Spain. [email protected]
PMID: 10476862 DOI: 10.1016/s0960-894x(99)00382-0
Abstract

Efficient syntheses of ent-isozonarol (6a), ent-isozonarone (7a) and ent-chromazonarol (8) from (-)-sclareol (12) are described. 6a and 7a show a significative antitumoral activity.