BN 80927: a novel homocamptothecin with inhibitory activities on both topoisomerase I and topoisomerase II

  • Bioorg Med Chem Lett. 1999 Sep 6;9(17):2599-602. doi: 10.1016/s0960-894x(99)00428-x.
O Lavergne  1 ,  J Harnett ,  A Rolland ,  C Lanco ,  L Lesueur-Ginot ,  D Demarquay ,  M Huchet ,  H Coulomb ,  D C Bigg
Affiliations
  • 1. Institut Henri Beaufour, Les Ulis, France.
PMID: 10498216 DOI: 10.1016/s0960-894x(99)00428-x
Abstract

BN 80927, a novel homocamptothecin derivative, inhibits both Topoisomerase I and Topoisomerase II mediated DNA relaxation and shows pronounced cytotoxicity against HT29, SKOV-3, DU145 and MCF7 human tumor cell lines.