A new benzoangelicin with strong photobiological activity

  • Bioorg Med Chem Lett. 2000 Jan 17;10(2):135-7. doi: 10.1016/s0960-894x(99)00640-x.
L Santana  1 ,  E Uriarte ,  L Dalla Via ,  O Gia
Affiliations
  • 1. Laboratorio de Química Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain.
PMID: 10673096 DOI: 10.1016/s0960-894x(99)00640-x
Abstract

Benzoangelicins 4-6 were synthesized in good yields from 7-hydroxy-5-methoxy-4-methylcoumarin (1). In the absence of UVA radiation, compounds 5 and 6 were only weakly active against HL60 and HeLa tumour cells; in its presence, compound 6 was 10 times more active than the reference compound 8-methoxypsoralen. None of 4-6 exhibited cutaneous phototoxicity.