Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity

  • Bioorg Med Chem Lett. 2000 Mar 6;10(5):495-8. doi: 10.1016/s0960-894x(00)00042-1.
D L Boger  1 ,  M Searcey ,  W C Tse ,  Q Jin
Affiliations
  • 1. Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. [email protected]
PMID: 10743956 DOI: 10.1016/s0960-894x(00)00042-1
Abstract

The series of four dimers derived from head to tail coupling of the two enantiomers of the duocarmycin SA alkylation subunit are described.