Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation

  • J Virol. 2000 May;74(10):4894-7. doi: 10.1128/jvi.74.10.4894-4897.2000.
K Doh-Ura  1 ,  T Iwaki ,  B Caughey
Affiliations
  • 1. Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. [email protected]
PMID: 10775631 DOI: 10.1128/jvi.74.10.4894-4897.2000
Abstract

We report that lysosomotropic agents and cysteine Protease Inhibitors inhibited protease-resistant Prion Protein accumulation in scrapie-infected neuroblastoma cells. The inhibition occurred without either apparent effects on normal Prion Protein biosynthesis or turnover or direct interactions with Prion Protein molecules. The findings introduce two new classes of inhibitors of the formation of protease-resistant Prion Protein.

Products