Flavonol-cinnamate cycloadducts and diamide derivatives from Aglaia laxiflora

  • J Nat Prod. 2000 Apr;63(4):473-6. doi: 10.1021/np990454d.
Y J Xu  1 ,  X H Wu ,  B K Tan ,  Y H Lai ,  J J Vittal ,  Z Imiyabir ,  L Madani ,  K S Khozirah ,  S H Goh
Affiliations
  • 1. Department of Chemistry, National University of Singapore.
PMID: 10785416 DOI: 10.1021/np990454d
Abstract

Leaf extracts of the Malaysian plant Aglaia laxiflora provided two cytotoxic compounds, a new rocaglaol rhamnoside (1), a known rocaglaol (2), new (but inactive) flavonol-cinnamaminopyrrolidine adducts (3-6), and their probable biosynthetic precursors (7 and trimethoxyflavonol). All structures were elucidated primarily by 2D NMR spectroscopy. The structure and stereochemistry of aglaxiflorin A (3) were confirmed by single-crystal X-ray crystallography.