A cytotoxic sesquiterpene caffeate from the liverwort Bazzanianovae-zelandiae

  • J Nat Prod. 2000 Apr;63(4):537-9. doi: 10.1021/np990492x.
E J Burgess  1 ,  L Larsen ,  N B Perry
Affiliations
  • 1. Plant Extracts Research Unit, New Zealand Institute for Crop & Food Research Limited, Department of Chemistry, University of Otago, Dunedin, New Zealand.
PMID: 10785435 DOI: 10.1021/np990492x
Abstract

Extracts of the liverwort Bazzania novae-zelandiae were cytotoxic, with selective activity against human tumor cell lines. Bioactivity-directed isolation work showed that the new compound naviculyl caffeate (1) was the main cytotoxin. This structure was confirmed by synthesis from the co-occurring sesquiterpene naviculol (2).