Structure-activity relationships of halichondrin B analogues: modifications at C.30-C.38

  • Bioorg Med Chem Lett. 2000 May 15;10(10):1029-32. doi: 10.1016/s0960-894x(00)00150-5.
Y Wang  1 ,  G J Habgood ,  W J Christ ,  Y Kishi ,  B A Littlefield ,  M J Yu
Affiliations
  • 1. Eisai Research Institute, Andover, MA 01810, USA.
PMID: 10843209 DOI: 10.1016/s0960-894x(00)00150-5
Abstract

Structurally simplified analogues of halichondrin B were prepared by total synthesis and found to retain potent cell growth inhibitory activity in vitro.