Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of a terminal halogen substitution in the side-chain

  • Bioorg Med Chem Lett. 2000 Jun 5;10(11):1215-7. doi: 10.1016/s0960-894x(00)00193-1.
A Brancale  1 ,  C McGuigan ,  G Andrei ,  R Snoeck ,  E De Clercq ,  J Balzarini
Affiliations
  • 1. Welsh School of Pharmacy, Cardiff University, UK.
PMID: 10866384 DOI: 10.1016/s0960-894x(00)00193-1
Abstract

Preliminary SAR studies on the side chain of a new class of Antiviral nucleosides have shown that terminal substitution in the side-chain, with a halogen atom, lead to potent and highly specific anti-VZV agents.