The design and synthesis of the high efficacy, non-peptide CCK1 receptor agonist PD170292

  • Bioorg Med Chem Lett. 2000 Jun 5;10(11):1245-8. doi: 10.1016/s0960-894x(00)00198-0.
N Bernad  1 ,  B G Burgaud ,  D C Horwell ,  R A Lewthwaite ,  J Martinez ,  M C Pritchard
Affiliations
  • 1. CCIPE-Faculte de Pharmacie, Montpellier, France.
PMID: 10866391 DOI: 10.1016/s0960-894x(00)00198-0
Abstract

The design, synthesis and biological actions of a novel, non-peptide CCK1 receptor agonist (PD 170292) which exhibits a similar pharmacological profile to the CCK analogue JMV180 is reported. PD 170292 was designed based on a consideration of the structures of a peptide based CCK1 receptor selective agonist and a peptoid CCK2 receptor selective antagonist.