7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma

  • Bioorg Med Chem Lett. 2000 Sep 18;10(18):2137-40. doi: 10.1016/s0960-894x(00)00426-1.
G Buckley  1 ,  N Cooper ,  H J Dyke ,  F Galleway ,  L Gowers ,  J C Gregory ,  D R Hannah ,  A F Haughan ,  P G Hellewell ,  H J Kendall ,  C Lowe ,  R Maxey ,  J G Montana ,  R Naylor ,  C L Picken ,  K A Runcie ,  V Sabin ,  B R Tuladhar ,  J B Warneck
Affiliations
  • 1. Celltech-Chiroscience Ltd, Abington, Cambridge, UK.
PMID: 10999488 DOI: 10.1016/s0960-894x(00)00426-1
Abstract

The synthesis and pharmacological profile of a novel series of 7-methoxybenzofuran-4-carboxamides is described. Some of these compounds were found to be potent inhibitors of phosphodiesterase type 4 (PDE4).