Ancistroealaines A and B, two new bioactive naphthylisoquinolines, and related naphthoic acids from Ancistrocladus ealaensis

  • J Nat Prod. 2000 Nov;63(11):1465-70. doi: 10.1021/np000247+.
G Bringmann  1 ,  A Hamm ,  C Günther ,  M Michel ,  R Brun ,  V Mudogo
Affiliations
  • 1. Institut für Organische Chemie der Universität, Am Hubland, D-97074 Würzburg, Germany. [email protected]
PMID: 11087584 DOI: 10.1021/np000247+
Abstract

Two new 5,8'-coupled naphthylisoquinoline Alkaloids, ancistroealaines A (1) and B (2), eleutherolic acid (3), and two naphthoic acids, ancistronaphthoic acid A (4) and B (5), have been isolated from Ancistrocladus ealaensis. Their structures were determined by spectroscopic, chemical, and chiroptical methods. Ancistroealaine A (1) exhibited activity against Leishmania donovani and Trypanosoma cruzi in vitro.