Synthesis and antiproliferative activity of benzocyclobutacarbazol derivatives. A new class of potential antitumor agents

  • Bioorg Med Chem Lett. 2000 Dec 4;10(23):2589-91. doi: 10.1016/s0960-894x(00)00532-1.
S Graf-Christophe  1 ,  C Kuehm-Caubère ,  P Renard ,  B Pfeiffer ,  A Pierré ,  S Léonce ,  P Caubère
Affiliations
  • 1. Institut de Chimie Organique et Analytique, associé au CNRS, Université d'Orléans, France.
PMID: 11128630 DOI: 10.1016/s0960-894x(00)00532-1
Abstract

Several benzocyclobutacarbazol derivatives were synthesized and evaluated for their potential cytotoxic properties. A number of these compounds exhibited significant antiproliferative activity with concomitant interaction with the cell cycle and represent a new class of potential Anticancer agents.