2,4,5-Trisubstituted imidazoles: novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 2

  • Bioorg Med Chem Lett. 2000 Dec 4;10(23):2603-5. doi: 10.1016/s0960-894x(00)00521-7.
C Zhang  1 ,  S Sarshar ,  E J Moran ,  S Krane ,  J C Rodarte ,  K D Benbatoul ,  R Dixon ,  A M Mjalli
Affiliations
  • 1. Ontogen Corporation, Carlsbad, CA 92009, USA.
PMID: 11128633 DOI: 10.1016/s0960-894x(00)00521-7
Abstract

Solution-phase combinatorial chemistry was applied to the optimization and development of clinical candidate OC144-093 (22), a novel and nontoxic modulator of P-glycoprotein mediated multidrug resistance.